Publication date: Available online 11 December 2017
Source:Brain Research Bulletin
Author(s): Jiao Yue, Xin-shang Wang, Yan-yan Guo, Kai-yin Zheng, Hai-yan Liu, Li-ning Hu, Ming-gao Zhao, Shui-bing Liu
Anxiety disorders are a category of mental disorders characterized by feelings of anxiety, stress, and fear attached to various sources. However, their pathogenesis is complicated and has not been fully elucidated. The amygdala is a vital brain region that regulates anxiety and mental disorders. Cytoplasmic polyadenylation element binding protein 1 (CPEB1) mediates the extension of the mRNA polyadenylation tail and facilitates the translation of target RNA. CPEB1 is closely related to neuronal diseases, such as Fragile X Syndrome, learning and memory disorders, and chronic pain. In this study, the role of CPEB1 in anxiety development was determined in a pain-mediated anxiety mouse model. The anxiety model was established in mice by injecting with complete Freund's adjuvant (CFA) into the hindpaw. CFA injection then led to anxiety-like behaviors and increased the CPEB1 levels in the mouse basolateral amygdala (BLA). CPEB1 enhancement facilitated the translation of GluA1, GluN2A, GluN2B, PSD95, and GABA receptors, which disturbed the E/I balance in the BLA as shown by enhanced excitatory presynaptic release and reduced inhibitory presynaptic release. CPEB1 knockdown with AAV-CPEB1-shRNA alleviated the anxiety-like behaviors but not the pain-like behaviors by enhancing inhibitory transmission in the BLA of model mice. The data suggest that CPEB1 participates in anxiety development by regulating excitatory/inhibitory synaptic transmission in the BLA.
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- Simple classifiers for molecular subtypes of color...
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- Radiofrequency-assisted subcision for postacne scars
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- Botulinum toxin type A for the treatment of locali...
- Cantharidin for treatment of facial molluscum cont...
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- Romance, love, and sex in the dermatology departme...
- Vitamin D deficiency in patients with alopecia are...
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- Iotaderma #287
- Andrews' diseases of the skin clinical atlas
- Cancer risks among patients with alopecia areata: ...
- Reply to: “Updated diagnostic criteria for frontal...
- Decreased risk of vitiligo in organ transplant rec...
- Vitiligo-like lesions in patients receiving anti–p...
- Trends in Medicare spending on topical immunomodul...
- Acknowledging the pseudo “fringe sign” in frontal ...
- High riding of brachiocephalic artery: A rare case...
- High riding of brachiocephalic artery: A rare case...
- Postoperative nausea and vomiting after unrestrict...
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- An actin cytoskeletal barrier inhibits lytic granu...
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- Haploinsufficiency of A20 causes autoinflammatory ...
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