CONTRIBUTION OF PHOTODYNAMIC THERAPY IN WOUND HEALING: A SYSTEMATIC REVIEW

Publication date: Available online 28 December 2017
Source:Photodiagnosis and Photodynamic Therapy
Author(s): Vanessa Nesi-Reis, Daniele Stéfanie Sara Lopes Lera-Nonose, Jully Oyama, Marielle Priscila Paula Silva-Lalucci, Izabel Galhardo Demarchi, Sandra Mara Alessi Aristides, Jorge Juarez Vieira Teixeira, Thaís Gomes Verzignassi Silveira, Maria Valdrinez Campana Lonardoni
ObjectiveWe researched articles that used photodynamic therapy (PDT) in skin wound healing in humans.MethodsThe systematic review was conducted throughout scientific articles that investigated the action of PDT on wound healing in humans, published from July 2005 to March 2017, in the data bases PubMed and LILACS.ResultsThe main types of wound described in selected articles in this review were chronic ulcer, non-melanoma skin cancer. For accomplishing the PDT, second generation of photosensitizing agents with laser or light emitting diode were used. The studies demonstrated that PDT contribute in several ways to the wound healing process: leading to cellular death; reducing or increasing inflammation; stimulating fibroblasts proliferation and, consequently, of collagen and elastin; raising transforming growth factor beta and metalloproteinases. Based on this, PDT provided good results in wound healing process, acting in several steps and accelerating tissue repair.ConclusionsPDT improved healing in many wound models in humans, revealing itself as a promising therapeutic modality, stimulating wound healing and remodelling.



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