Control of innate-like B cell location for compartmentalised IgM production

Publication date: February 2018
Source:Current Opinion in Immunology, Volume 50
Author(s): Lucy H Jackson-Jones, Cécile Bénézech
Natural IgM are crucial for early protection against infection and play an important homeostatic function by clearing dead cells. The production of IgM is ensured by a population of B cells with innate-like properties: their response is rapidly activated by innate signals early during the onset of infection. The main reservoir of innate-like B cells (IBCs) are the serous cavities, but their maintenance and activation depends on their relocation to a variety of lymphoid tissues. Recent advances indicate that fat-associated lymphoid clusters (FALCs) and milky spots contribute to local IgM secretion and play a central role in the localisation and regulation of IBC function.

Graphical abstract

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