Could calcium channel blockers treat 2 illnesses with 1 pill?

Ever since Middleton's1 suggestion that excessive permeability of airway cells to calcium ions might play a role in the underlying mechanism of bronchial hyperresponsiveness (BHR) and asthma, researchers have questioned whether calcium channel blockers (CCBs) might be efficacious in the treatment of this illness. Their potential utility makes a great deal of sense, because cytoplasmic calcium is involved in bronchoconstriction, mast cell mediator release, vagal reflex stimulation, airway mucous gland secretion, chemotaxis of eosinophils, and possibly even smooth muscle remodeling.

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