Coumarins as promising scaffold for the treatment of age-related diseases - an overview of the last five years.

Coumarins as promising scaffold for the treatment of age-related diseases - an overview of the last five years.

Curr Top Med Chem. 2017 Dec 14;:

Authors: Delogu GL, Matos MJ

Abstract
Degenerative diseases are becoming increasingly prevalent with the aging of the human population. The twentieth century witnessed a significant demographic change in the industrialized world that is currently followed by a similar shift of life expectancy to upper age ranges in Asia, Africa, and Middle and South America. A rising tide of chronic age-dependent diseases will soon present serious challenges for these countries. Age-related diseases are commonly seen in older patients. More than 40% of adults 60 and older have a combination of risk factors known as metabolic syndrome, which increases the risk for developing degenerative disorders, and certain cancers. Among these, Parkinson's, Alzheimer's and cardiovascular diseases are heading the table. The development of effective cardio- and neuroprotective therapies that slow down or stop disease's progression in the earliest stages is one of the main goals of researchers working on this area. A wide range of different substituted coumarins and their biological properties are well known due to their synthetic accessibility, along with their abundant presence in plants and others natural products. These heterocyclic compounds play an important role in a variety of areas, but stand out in the field of Medicinal Chemistry. This review provides an overview of the last five years about the potential of coumarins as modulators of several physiological mechanisms involved in age-related pathologies.

PMID: 29243580 [PubMed - as supplied by publisher]

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