Genetic variants in the VEGF pathway as prognostic factors in stages II and III colon cancer.

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Genetic variants in the VEGF pathway as prognostic factors in stages II and III colon cancer.

Pharmacogenomics J. 2017 Dec 27;:

Authors: Riera P, Virgili AC, Salazar J, Sebio A, Tobeña M, Sullivan I, Páez D

Abstract
The role of vascular endothelial growth factor (VEGF) gene polymorphisms in the prognosis of colon cancer prognosis remains unclear. We evaluated the influence of 28 single-nucleotide polymorphisms in 12 genes in the VEGF pathway on the prognosis of 347 patients with stage II-III colon cancer. We found that rs9513070 (VEGFR1) and rs1137282 (KRAS) were associated with overall survival in stage II colon cancer patients (p = 0.025 and p = 0.001, respectively). When primary tumor location was considered, rs9513070 was also associated with relapse-free and overall survival (p = 0.033 and p = 0.031, respectively) in left colon cancer patients. Additionally, rs35251833 in the ITGAV gene correlated with relapse-free survival (p = 0.032). This study provides evidence that germline polymorphisms in VEGFR1, KRAS and ITGAV genes are associated with prognosis in stages II-III colon cancer patients. As stage and tumor location are correlated with prognosis, future genetic studies should stratify colon cancer patients according to these parameters.

PMID: 29282362 [PubMed - as supplied by publisher]

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