Impact of early access to multidisciplinary care on treatment outcomes in patients with skull base chordoma.

Related Articles

Impact of early access to multidisciplinary care on treatment outcomes in patients with skull base chordoma.

Acta Neurochir (Wien). 2017 Dec 21;:

Authors: Freeman JL, DeMonte F, Al-Holou W, Gidley PW, Hanna EY, Kupferman ME, Su SY, Raza SM

Abstract
OBJECTIVE: To determine if early access to multidisciplinary surgical care affects outcomes in patients with skull base chordoma.
METHOD: A retrospective chart review of prospectively collected data was performed on 51 patients treated from 1993 to 2014. The cohort was divided into those presenting (1) for initial management (ID, n = 21) or (2) with persistent/progressive disease after prior biopsy/surgery (PD, n = 30) outside of a multidisciplinary setting. The impact of initial surgical management in a multidisciplinary center on progression-free survival (PFS) was assessed with Kaplan-Meier and log-rank analyses.
RESULTS: Mean follow-up, median PFS, median overall survival (OS), and 10-year OS for the entire cohort was 70 months, 47 months, 159 months, and 19%, respectively. Initial management in a multidisciplinary center resulted in a significant improvement in PFS versus initial surgery with or without radiotherapy (XRT) outside of this setting (64 vs 25 months, p = 0.035). Initial surgical resection outside of a multidisciplinary setting increased the risk of recurrence/progression on univariate (HR, 2.276; p = 0.022) and multivariate analysis (HR, 2.831; p = 0.006), respectively.
CONCLUSIONS: The results from this study emphasize the impact that coordinated multidisciplinary surgical care has on patient outcomes for chordomas of the clivus. Biopsy followed by attempted radical resection at a dedicated center does not affect PFS and, therefore, represents a reasonable first step in management for patients presenting outside of multidisciplinary setting.

PMID: 29270681 [PubMed - as supplied by publisher]

http://ift.tt/2DDbUsu