Platelet-to-lymphocyte ratio predicts long-term survival in laryngeal cancer.

Platelet-to-lymphocyte ratio predicts long-term survival in laryngeal cancer.

Eur Arch Otorhinolaryngol. 2017 Dec 23;:

Authors: Mao Y, Fu Y, Gao Y, Yang A, Zhang Q

Abstract
OBJECTIVES: Although the survival rate of laryngeal cancer is relatively high, some patients with laryngeal squamous cell carcinoma (LSCC) show the least benefit from laryngectomy, owing to few determining diagnostic tools. We aimed to identify high-risk patients according to a preoperatively determined signature of the platelet-to-lymphocyte ratio (PLR) of > 193.55, as an indicator of poor treatment outcome in LSCC patients.
METHODS: We retrospectively evaluated 899 patients who underwent laryngectomy for LSCC. The patients were stratified by PLR into three subgroups: low (≤ 119.55), moderate (> 119.55 and ≤ 193.55), and high (> 193.55). Kaplan-Meier curves were plotted to compare the intergroup cancer-specific survival (CSS).
RESULTS: Patients with high PLR had significantly worse survival outcomes (5-year CSS, low vs. moderate vs. high: 75.3 vs. 68.4 vs. 53.9%; 10-year CSS, low vs. moderate vs. high: 65.0 vs. 56.0 vs. 38.6%, P < 0.001). Patients with PLR > 193.55 represented malnutrition and more advanced cancer stage..
CONCLUSION: Patients with PLR > 193.55 experience poor outcomes and represent malnutrition, more advanced cancer stage.

PMID: 29275426 [PubMed - as supplied by publisher]

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