Risk factors associated with meningitis after neurosurgery operation: a retrospective cohort study in a Chinese hospital.

Risk factors associated with meningitis after neurosurgery operation: a retrospective cohort study in a Chinese hospital.

World Neurosurg. 2017 Dec 27;:

Authors: Chen S, Cui A, Yu K, Huang C, Zhu M, Chen M

Abstract
OBJECTIVE: Meningitis is a serious complication occurring after neurosurgical operations, which can result in severe morbidity and high mortality. This retrospective cohort study aimed to determine the risk factors of postoperative meningitis in a large clinical center of Neurosurgery in China.
METHODS: Patients who underwent neurosurgeries between January 2014 and December 2015 were selected and 1016 cases were included the final analysis. On the basis of propensity scores, 84 post-operative meningitis patients were successfully matched to the 84 patients without post-operative meningitis.
RESULTS: After propensity score matching, age, hospitalization duration, intraoperative use of corticoids, intraoperative use of antibiotics, external ventricular drainage, lumbar drainage, enteral nutrition, surgery duration, major craniotomy and transsphenoidal surgery were associated with post-operative meningitis. Also, we further confirmed preoperative use of corticoids, intraoperative use of corticoids, intraoperative use of antibiotics, external ventricular drainage, lumbar drainage, and major craniotomy were independent predictors of postoperative meningitis in propensity score-matched cohort. Then prediction model including these 6 independent predictors above was established. Finally, ROC curve and discriminant analysis validated this model has strong predictive power to evaluate post-operative meningitis.
CONCLUSION: The prediction model built in our study can be an excellent tool to predict meningitis after neurosurgical procedures.

PMID: 29288858 [PubMed - as supplied by publisher]

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