Publication date: February 2018
Source:International Immunopharmacology, Volume 55
Author(s): Jing Wang, Mengzhu Zheng, Qiuxia Min, Ya Gao, Weiguang Sun
Lienal peptide (LP), extracted from the spleen of healthy calves, has been reported to be a unique immune modulator which shows notable immunomodulatory effects on immune system function. This study was designed to further investigate the immunomodulatory effect of LP in vitro and in vivo. The results showed that LP significantly decreased the LPS-induced overexpression levels of pro-inflammatory cytokines including IL-1β, IL-15, TNF-α and MIP-1α, through the NF-κB pathway. Moreover, LP showed an immunologic enhancement effect on immunosuppressed mice which were induced by cytarabine. The percentage of activated cells for bone marrow B lymphocytes, spleen lymphocytes, NK cells and peritoneal macrophages were notably increased after LP treatment. Furthermore, the administration of LP significantly reduced DNFB-induced inflammatory cell infiltration and restored CFA-induced arthritis in rats as evidenced by decrease in paw swelling and regulation of cytokines balance in serum. In conclusion, LP has outstanding immunomodulatory activity and could be served as a potential candidate for the management of patients with immune system disorders.
http://ift.tt/2DzoXv1
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
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00302841026182
00306932607174
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- Intractable hyperemesis gravidarum in a patient wi...
- Intradural lumbar disc herniation detected by 3D C...
- Shah-Waardenburg syndrome: a case highlighting the...
- Solid pseudopapillary tumour (Frantzs tumour) of t...
- Unusual case of anxiety: trichloroethylene neuroto...
- Cutaneous infection with paucibacillary Mycobacter...
- Short-course high-dose ibuprofen causing both earl...
- Oyster-related tenosynovitis: a rare case of Mycob...
- HHV-8-associated haemophagocytic lymphohistiocytos...
- Chickenpox: an ageless disease
- Osteoid bezoar: a rare case causing small bowel ob...
- Syndrome of X linked intellectual disability, epil...
- Idiopathic bilateral hypertrophic olivary degenera...
- Contemporary non-surgical approach for faecal dive...
- Variant of Lemierres syndrome with internal jugula...
- Correction: Gangrenous digital infarcts in a sever...
- Double hit! A unique case of resistant hypertension
- Epstein–Barr virus exanthem in an adult patient wi...
- Ischaemic ulcers on the toes secondary to Raynaud ...
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- Putative role of attractive and repulsive forces i...
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