Publication date: Available online 28 November 2017
Source:Clinical Therapeutics
Author(s): Violet Lagari, Tara Gavcovich, Silvina Levis
PurposeThe American College of Physicians (ACP) published a set of guidelines on how to prevent fractures in men and women with low bone density or osteoporosis. As the population ages, the overall risk of fractures increases, thus burdening the health care system. These guidelines review current evidence for osteoporosis management, providing an update to the previous 2008 ACP's guidelines.MethodsThe ACP put forth 6 recommendations addressing the complexities in osteoporosis management based on evidence available through October 2016 with a focus on bisphosphonates, calcium, vitamin D, and estrogen. Evidence was graded according to recommended strength by using the ACP standard methods.FindingsThe ACP recommends anti-osteoporosis therapy with 1 of 3 bisphosphonates (alendronate, risedronate, or zoledronic acid) or denosumab in patients with osteoporosis, while excluding anabolic therapies, and recommends against raloxifene. Although bisphosphonates are the mainstay of treatment, anabolic therapy and raloxifene may be used in specific situations. Pharmacologic therapy is recommended for 5 years, oversimplifying length of therapy and failing to promote an individualized patient-centered care approach. Moreover, abrupt discontinuation of denosumab is associated with a decline in bone mineral density (BMD), which must be addressed. Routine monitoring of BMD by dual x-ray absorptiometry is not endorsed during treatment, which leads to underrecognition of management issues. Pharmacologic treatment with bisphosphonates for male osteoporosis is recommended, although therapies such as denosumab and teriparatide are excluded. Finally, the ACP recommends treatment for women aged ≥65 years at high risk for fracture with osteopenia after a discussion of patient preferences, fracture risk profile, and medications.ImplicationsOsteoporosis management is complex. The 2017 ACP guidelines address challenges faced by clinicians but oversimplify more complex issues. These are among a number of guidelines that are available for osteoporosis management, which may be used in combination with other sources to assist clinicians with diagnostic and management strategies.
http://ift.tt/2ojiAsp
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
Αρχειοθήκη ιστολογίου
-
►
2023
(391)
- ► Φεβρουαρίου (200)
- ► Ιανουαρίου (191)
-
►
2022
(2843)
- ► Δεκεμβρίου (161)
- ► Σεπτεμβρίου (219)
- ► Φεβρουαρίου (264)
- ► Ιανουαρίου (280)
-
►
2021
(5625)
- ► Δεκεμβρίου (231)
- ► Σεπτεμβρίου (345)
- ► Φεβρουαρίου (620)
-
►
2020
(2065)
- ► Δεκεμβρίου (535)
- ► Σεπτεμβρίου (222)
- ► Φεβρουαρίου (28)
-
►
2019
(9608)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3791)
- ► Ιανουαρίου (3737)
-
►
2018
(69720)
- ► Δεκεμβρίου (3507)
- ► Σεπτεμβρίου (3851)
- ► Φεβρουαρίου (8116)
- ► Ιανουαρίου (7758)
-
▼
2017
(111579)
-
▼
Δεκεμβρίου
(7718)
-
▼
Δεκ 16
(359)
- Multiparametric MR imaging of the Prostate
- Prostate MR Imaging
- Circulating tumour DNA, a promising biomarker for ...
- A SYSTEMATIC REVIEW OF THE SAFETY PROFILE OF THE D...
- Design, synthesis, and evaluation of polyamine-mem...
- Supported carbon dots serve as high-performance ad...
- Preliminary survey of matrix effects in the Microw...
- Turn-on fluorescent sensor for the detection of gl...
- Theta-burst modulation of mid-ventrolateral prefro...
- The effect of gender, age and product type on the ...
- Toward new forms of meal sharing? Collective habit...
- Editorial Board
- Do the right thing: neural network mechanisms of m...
- The significant prognostic value of circulating tu...
- Breast cancer and synchronous multiple myeloma as ...
- Hepatocellular carcinoma in the era of immunotherapy
- Locally advanced pancreatic cancer: An emerging en...
- Is the limit of 60mg of oral morphine equivalent d...
- Meta-analysis of safety and efficacy of rolapitant...
- Title Page
- Information for Readers
- Table of Contents
- Familial Colorectal Cancer Type X (FCCTX) and the ...
- Anti-PD1/PDL1 induced psoriasis
- Complications in the treatment of mandibular condy...
- Effect of different resistance-training protocols ...
- Editorial Board
- OBC
- Ultrasound assessment of soft tissue augmentation ...
- Distribution and neurochemistry of porcine urinary...
- Polymer nanostructures for bioapplications induced...
- Effects of Xiao Yao San on Interferon-α-Induced De...
- Role of the orexin receptors within the nucleus ac...
- Evaluation of patients' compliance in different ag...
- Prevalence of dental caries among schoolchildren f...
- Disease tolerance: concept and mechanisms
- Suppression of NLRP3 attenuates hemorrhagic transf...
- A severe female case of arthrogryposis multiplex c...
- Prevalence of dental caries among schoolchildren f...
- Opposing Post-transcriptional Control of InR by FM...
- Integration of GPCR Signaling and Sorting from Ver...
- Glucocorticoid Receptor Binding Induces Rapid and ...
- Hepatic Dysfunction Caused by Consumption of a Hig...
- A Small-Molecule Oligosaccharyltransferase Inhibit...
- Integrating Extracellular Flux Measurements and Ge...
- Melanoma Therapeutic Strategies that Select agains...
- Strict Independence of Parallel and Poly-synaptic ...
- ATP Citrate Lyase Regulates Myofiber Differentiati...
- Infrabarrels Are Layer 6 Circuit Modules in the Ba...
- Cell Type of Origin Dictates the Route to Pluripot...
- Nucleus Accumbens Dopamine Signaling Regulates Sex...
- Control of Huntington’s Disease-Associated Phenoty...
- An Elongin-Cullin-SOCS Box Complex Regulates Stres...
- Nutritive, Post-ingestive Signals Are the Primary ...
- Functional and Molecular Characterization of Mecha...
- Convergence of BMI1 and CHD7 on ERK Signaling in M...
- Ultradeep mapping of neuronal mitochondrial deleti...
- Computer-aided design and manufacture of hyrax dev...
- IgE promotes type 2 innate lymphoid cells in murin...
- Typical sensory organization test findings and cli...
- Mixed messages
- The Burden of Inbox-Messaging Systems and Its Effe...
- Fibrous Cephalic Plaques in Tuberous Sclerosis Com...
- A systematic review of validated sinus surgery sim...
- Prevalence of skin disease in a population based s...
- Scleroderma skin ulcers definition, classification...
- Clinical and immunological aspects of anti-peptidy...
- Pitfalls in the detection of citrullination and ca...
- Imaging modalities for the diagnosis and disease a...
- A concise review of significantly modified serolog...
- NK cells in autoimmune diseases: Linking innate an...
- Curcumin: A natural modulator of immune cells in s...
- Belimumab in the treatment of systemic lupus eryth...
- Clinical and microbiological characteristics of th...
- Childhood- versus adult-onset ANCA-associated vasc...
- Oropharynx-directed ipsilateral irradiation for p1...
- American Thyroid Association ultrasound system for...
- The mechanism of skin lipids influencing skin status
- Dysregulation of autophagy in melanocytes contribu...
- Editorial board
- Cold atmospheric plasma (CAP) activates angiogenes...
- Sweat mechanisms and dysfunctions in atopic dermat...
- Circulating long non-coding RNA MALAT1 expression ...
- Genetic analysis and clinical description of Greek...
- Assessment of a FBXW8 frameshift mutation, c.1312_...
- A leukemic double-hit follicular lymphoma associat...
- ALK-TPM3 rearrangement in adult renal cell carcino...
- Characterization of novel, large duplications in t...
- SVAtools for junction detection of genome-wide chr...
- Discussion on reply to Foley et al., ‘Acute myeloi...
- Reply to Foley et al., “Acute myeloid leukemia wit...
- Changing temporal trends in non-AIDS cancer mortal...
- Cancers in France in 2015 attributable to high bod...
- Incidence, prevalence, mortality, disability-adjus...
- Improvement of relative survival in elderly patien...
- Missing data and chance variation in public report...
- Nationwide analysis on the impact of socioeconomic...
- Title page / Editorial Board
- Table of contents
- Peptide fingerprinting of the sea anemone Heteract...
-
▼
Δεκ 16
(359)
- ► Σεπτεμβρίου (7549)
- ► Φεβρουαρίου (10753)
- ► Ιανουαρίου (10529)
-
▼
Δεκεμβρίου
(7718)
-
►
2016
(16402)
- ► Δεκεμβρίου (7478)
- ► Φεβρουαρίου (900)
- ► Ιανουαρίου (1250)
! # Ola via Alexandros G.Sfakianakis on Inoreader
Η λίστα ιστολογίων μου
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Αρχειοθήκη ιστολογίου
-
►
2023
(391)
- ► Φεβρουαρίου (200)
- ► Ιανουαρίου (191)
-
►
2022
(2843)
- ► Δεκεμβρίου (161)
- ► Σεπτεμβρίου (219)
- ► Φεβρουαρίου (264)
- ► Ιανουαρίου (280)
-
►
2021
(5625)
- ► Δεκεμβρίου (231)
- ► Σεπτεμβρίου (345)
- ► Φεβρουαρίου (620)
-
►
2020
(2065)
- ► Δεκεμβρίου (535)
- ► Σεπτεμβρίου (222)
- ► Φεβρουαρίου (28)
-
►
2019
(9608)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3791)
- ► Ιανουαρίου (3737)
-
►
2018
(69720)
- ► Δεκεμβρίου (3507)
- ► Σεπτεμβρίου (3851)
- ► Φεβρουαρίου (8116)
- ► Ιανουαρίου (7758)
-
▼
2017
(111579)
-
▼
Δεκεμβρίου
(7718)
-
▼
Δεκ 16
(359)
- Multiparametric MR imaging of the Prostate
- Prostate MR Imaging
- Circulating tumour DNA, a promising biomarker for ...
- A SYSTEMATIC REVIEW OF THE SAFETY PROFILE OF THE D...
- Design, synthesis, and evaluation of polyamine-mem...
- Supported carbon dots serve as high-performance ad...
- Preliminary survey of matrix effects in the Microw...
- Turn-on fluorescent sensor for the detection of gl...
- Theta-burst modulation of mid-ventrolateral prefro...
- The effect of gender, age and product type on the ...
- Toward new forms of meal sharing? Collective habit...
- Editorial Board
- Do the right thing: neural network mechanisms of m...
- The significant prognostic value of circulating tu...
- Breast cancer and synchronous multiple myeloma as ...
- Hepatocellular carcinoma in the era of immunotherapy
- Locally advanced pancreatic cancer: An emerging en...
- Is the limit of 60mg of oral morphine equivalent d...
- Meta-analysis of safety and efficacy of rolapitant...
- Title Page
- Information for Readers
- Table of Contents
- Familial Colorectal Cancer Type X (FCCTX) and the ...
- Anti-PD1/PDL1 induced psoriasis
- Complications in the treatment of mandibular condy...
- Effect of different resistance-training protocols ...
- Editorial Board
- OBC
- Ultrasound assessment of soft tissue augmentation ...
- Distribution and neurochemistry of porcine urinary...
- Polymer nanostructures for bioapplications induced...
- Effects of Xiao Yao San on Interferon-α-Induced De...
- Role of the orexin receptors within the nucleus ac...
- Evaluation of patients' compliance in different ag...
- Prevalence of dental caries among schoolchildren f...
- Disease tolerance: concept and mechanisms
- Suppression of NLRP3 attenuates hemorrhagic transf...
- A severe female case of arthrogryposis multiplex c...
- Prevalence of dental caries among schoolchildren f...
- Opposing Post-transcriptional Control of InR by FM...
- Integration of GPCR Signaling and Sorting from Ver...
- Glucocorticoid Receptor Binding Induces Rapid and ...
- Hepatic Dysfunction Caused by Consumption of a Hig...
- A Small-Molecule Oligosaccharyltransferase Inhibit...
- Integrating Extracellular Flux Measurements and Ge...
- Melanoma Therapeutic Strategies that Select agains...
- Strict Independence of Parallel and Poly-synaptic ...
- ATP Citrate Lyase Regulates Myofiber Differentiati...
- Infrabarrels Are Layer 6 Circuit Modules in the Ba...
- Cell Type of Origin Dictates the Route to Pluripot...
- Nucleus Accumbens Dopamine Signaling Regulates Sex...
- Control of Huntington’s Disease-Associated Phenoty...
- An Elongin-Cullin-SOCS Box Complex Regulates Stres...
- Nutritive, Post-ingestive Signals Are the Primary ...
- Functional and Molecular Characterization of Mecha...
- Convergence of BMI1 and CHD7 on ERK Signaling in M...
- Ultradeep mapping of neuronal mitochondrial deleti...
- Computer-aided design and manufacture of hyrax dev...
- IgE promotes type 2 innate lymphoid cells in murin...
- Typical sensory organization test findings and cli...
- Mixed messages
- The Burden of Inbox-Messaging Systems and Its Effe...
- Fibrous Cephalic Plaques in Tuberous Sclerosis Com...
- A systematic review of validated sinus surgery sim...
- Prevalence of skin disease in a population based s...
- Scleroderma skin ulcers definition, classification...
- Clinical and immunological aspects of anti-peptidy...
- Pitfalls in the detection of citrullination and ca...
- Imaging modalities for the diagnosis and disease a...
- A concise review of significantly modified serolog...
- NK cells in autoimmune diseases: Linking innate an...
- Curcumin: A natural modulator of immune cells in s...
- Belimumab in the treatment of systemic lupus eryth...
- Clinical and microbiological characteristics of th...
- Childhood- versus adult-onset ANCA-associated vasc...
- Oropharynx-directed ipsilateral irradiation for p1...
- American Thyroid Association ultrasound system for...
- The mechanism of skin lipids influencing skin status
- Dysregulation of autophagy in melanocytes contribu...
- Editorial board
- Cold atmospheric plasma (CAP) activates angiogenes...
- Sweat mechanisms and dysfunctions in atopic dermat...
- Circulating long non-coding RNA MALAT1 expression ...
- Genetic analysis and clinical description of Greek...
- Assessment of a FBXW8 frameshift mutation, c.1312_...
- A leukemic double-hit follicular lymphoma associat...
- ALK-TPM3 rearrangement in adult renal cell carcino...
- Characterization of novel, large duplications in t...
- SVAtools for junction detection of genome-wide chr...
- Discussion on reply to Foley et al., ‘Acute myeloi...
- Reply to Foley et al., “Acute myeloid leukemia wit...
- Changing temporal trends in non-AIDS cancer mortal...
- Cancers in France in 2015 attributable to high bod...
- Incidence, prevalence, mortality, disability-adjus...
- Improvement of relative survival in elderly patien...
- Missing data and chance variation in public report...
- Nationwide analysis on the impact of socioeconomic...
- Title page / Editorial Board
- Table of contents
- Peptide fingerprinting of the sea anemone Heteract...
-
▼
Δεκ 16
(359)
- ► Σεπτεμβρίου (7549)
- ► Φεβρουαρίου (10753)
- ► Ιανουαρίου (10529)
-
▼
Δεκεμβρίου
(7718)
-
►
2016
(16402)
- ► Δεκεμβρίου (7478)
- ► Φεβρουαρίου (900)
- ► Ιανουαρίου (1250)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου