The neonatal window of opportunity – early priming for life

Publication date: Available online 14 December 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Harald Renz, Becky D. Adkins, Sina Bartfeld, Richard S. Blumberg, Donna L. Farber, Johan Garssen, Peter Ghazal, David J. Hackam, Benjamin J. Marsland, Kathy D. McCoy, John Penders, Immo Prinz, Valerie Verhasselt, Erika von Mutius, Jeffrey N. Weiser, Duane R. Wesemann, Mathias W. Hornef
The concept of the neonatal window of opportunity assigns the early postnatal period a critical role for life-long host-microbial and immune homeostasis. It is supported by epidemiological evidence that links postnatal environmental exposure with disease susceptibility and mechanisms in the neonate host that facilitate the postnatal transposition, establish a stable microbiome and promote immune maturation. During the conference on "The neonatal window of opportunity – early priming for life", postnatal microbiome and immune maturation, epidemiological evidence and fundamental mechanisms were discussed to identify new targets for future preventive and interventional measures.



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