The TCR Takes Some Immune Responsibility

Publication date: 21 November 2017
Source:Immunity, Volume 47, Issue 5
Author(s): Ashley A. Viehmann Milam, Paul M. Allen
In this issue of Immunity, Van Braeckel-Budimir et al. (2017) reveal that the pathogenic response of mice to a Plasmodium berghei infection is dominated by a Vβ8.1 T cell response. Mice lacking Vβ8.1 T cells fail to mount a pathogenic response, thus showing that the TCR locus can be an Immune response (Ir) gene.

Teaser

In this issue of Immunity, Van Braeckel-Budimir et al. (2017) reveal that the pathogenic response of mice to a Plasmodium berghei infection is dominated by a Vβ8.1 T cell response. Mice lacking Vβ8.1 T cells fail to mount a pathogenic response, thus showing that the TCR locus can be an Immune response (Ir) gene.


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