Waste Not, Want Not: Lactate Oxidation Fuels the TCA Cycle

Publication date: 5 December 2017
Source:Cell Metabolism, Volume 26, Issue 6
Author(s): Inmaculada Martínez-Reyes, Navdeep S. Chandel
Previous studies have demonstrated that mitochondrial respiration is essential for tumorigenesis. Hui et al. (2017) and Faubert et al. (2017) demonstrate that lactate, traditionally viewed as a waste product of anaerobic and aerobic glycolysis, is a major carbon source to fuel the mitochondrial TCA cycle in normal tissue and in tumors.

Teaser

Previous studies have demonstrated that mitochondrial respiration is essential for tumorigenesis. Hui et al. and Faubert et al. demonstrate that lactate, traditionally viewed as a waste product of anaerobic and aerobic glycolysis, is a major carbon source to fuel the mitochondrial TCA cycle in normal tissue and in tumors.


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