Association of clinical trial enrollment and survival using contemporary therapy for pediatric acute lymphoblastic leukemia.

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Association of clinical trial enrollment and survival using contemporary therapy for pediatric acute lymphoblastic leukemia.

Pediatr Blood Cancer. 2018 Feb;65(2):

Authors: Moke DJ, Oberley MJ, Bhojwani D, Parekh C, Orgel E

Abstract
While early studies reported superior survival for cancer patients enrolled on clinical trials, recent findings are inconclusive. We investigated the association between enrollment on contemporary trials and event-free survival (EFS) in pediatric B-cell acute lymphoblastic leukemia (B-ALL). In a retrospective cohort of 274 children (1-21 years) treated for B-ALL from 2008 to 2015, 55.5% enrolled with no disparity in enrollment by age, sex, or ethnicity. Three-year EFS was similar for enrolled and not enrolled patients (90.1% [95% CI, 82.5-94.5] versus 86.5% [95% CI, 77.7-92.0]). Clinical trial enrollment did not affect pediatric B-ALL survival, albeit in a limited-size cohort treated at a single academic institution.

PMID: 28876513 [PubMed - indexed for MEDLINE]

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