Correlation between Tumor Location and Clinical Properties of Glioblastomas in Frontal and Temporal Lobes.

Correlation between Tumor Location and Clinical Properties of Glioblastomas in Frontal and Temporal Lobes.

World Neurosurg. 2018 Jan 17;:

Authors: Li HY, Sun CR, He M, Yin LC, Du HG, Zhang JM

Abstract
BACKGROUND: Tumor location is a major prognostic factor in glioblastoma and may associate with clinical properties. The present study established and analyzed the correlation between tumor location and clinical properties of glioblastomas in frontal and temporal lobes.
METHODS: This retrospective study determined the location of glioblastoma, frontal lobe(FL) or temporal lobe (TL), based on preoperative MR images. The glioblastomas in FL at clinical, radiological, and molecular levels were explored to define their clinical properties, including gender, age, sides, relationship to the ventricle, imaging subtypes, volumetrics, IDH mutation, promoter methylation of MGMT, PFS and OS as compared to glioblastomas in TL.
RESULTS: A total of 406 patients were enrolled: 182 (44.83%) and 224 (55.17%) in FL and TL groups, respectively, with a mean age of 69.8 years. Compared to FL, TL had a higher incidence of female patients(P=0.024), distant to the ventricle(P=0.006), IDH mutation(P=0.021), promoter methylation of MGMT(P=0.012), and prolonged PFS and OS(P<0.05) in glioblastomas patients. No significant differences were observed with respect to age ≥60y at study entry(P= 0.668), sides(P= 0.879), imaging subtypes(P= 0.362), or volumetrics (P=0.709) between the two groups.
CONCLUSIONS: This study demonstrated that different tumor locations are associated with diverse clinical properties of glioblastoma in FL and TL. This would aid in increasing our understanding of glioblastoma biology for application in baseline comparisons in future clinical trials.

PMID: 29355809 [PubMed - as supplied by publisher]

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