Detection of synchronous primary lung adenocarcinomas with genomic sequencing

Publication date: Available online 11 January 2018
Source:Annals of Diagnostic Pathology
Author(s): Debra Berry, Mani Mahadevan, Mark R. Wick
In the setting of synchronous pulmonary carcinomas, distinguishing between a monoclonal process with intrapulmonary metastasis and two independent tumors has significant therapeutic and prognostic implications. We describe two cases in which molecular profiling was used to characterize synchronous, primary pulmonary tumors and guide clinical management. In both cases, the patients underwent surgical resection without adjuvant chemotherapy or radiation and remain free of disease.



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