Efficient role of IgH 3' regulatory region deficient B-cells in the development of oil granulomas.

Related Articles

Efficient role of IgH 3' regulatory region deficient B-cells in the development of oil granulomas.

Oncotarget. 2016 Jun 21;7(25):38741-38749

Authors: Ghazzaui N, Saintamand A, Issaoui H, Saad F, Denizot Y

Abstract
Functional B-cells are essential for the formation of oil granulomas. The IgH 3' regulatory region (3'RR) activates important check-points during B-cell maturation. We investigated if 3'RR-deficient B-cells remain efficient to develop oil granulomas in response to pristine. B-cells expressing an IgH 3'RR-deficient allele were similarly recruited to wild type allele expressing B-cells in the granuloma. No differences were observed between 3'RR-deficient mice and control mice for granuloma numbers, cellular composition and ability to express mRNA transcripts for several pro- and anti-inflammatory cytokines. Altogether these results suggest a normal role for 3'RR-deficient B-cells in the development of an acute B-cell-mediated inflammatory response.

PMID: 27231852 [PubMed - indexed for MEDLINE]

http://ift.tt/2DF7k05