Fatal course of Saprochaete capitata fungemia in children with acute lymphoblastic leukemia.

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Fatal course of Saprochaete capitata fungemia in children with acute lymphoblastic leukemia.

Pediatr Hematol Oncol. 2017 Mar;34(2):66-72

Authors: Özdemir ZC, Bozkurt Turhan A, Düzenli Kar Y, Dinleyici ÇE, Bör Ö

Abstract
Saprochaete capitata (S. capitata) is a very rare fungal pathogen that causes disseminated opportunistic infections in patients with hematologic malignancies. Fever resistant to broad-spectrum antibiotic and antifungal treatment is common in the presence of fungemia during the period of profound neutropenia. We describe three cases of leukemic children who died from S. capitata fungemia following a first febrile neutropenic episode after the induction of chemotherapy. S. capitata fungemia is an emergent infection associated with high mortality and low susceptibility to fluconazole and echinocandins. Awareness of this emergent infection is needed to ensure that it can be properly treated.

PMID: 28574735 [PubMed - indexed for MEDLINE]

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