Filaggrin gene mutations may influence the persistence of food allergies in Japanese primary school children.

Filaggrin gene mutations may influence the persistence of food allergies in Japanese primary school children.

Br J Dermatol. 2018 Jan 25;:

Authors: Kono M, Akiyama M, Inoue Y, Nomura T, Hata A, Okamoto Y, Takeichi T, Muro Y, McLean WHI, Shimizu H, Sugiura K, Suzuki Y, Shimojo N

Abstract
Mutations in FLG are the underlying cause of ichthyosis vulgaris and are an important predisposing factor for atopic dermatitis (AD).1 In 2011, FLG mutations were reported to increase the risk of peanut allergy2 , and they have been proven to increase the risk of other food sensitizations and allergies.3,4 In this study, we comprehensively screened 411 children in Japan for 10 Japanese-population-specific FLG mutations and suggested that FLG mutations influence the persistence of food allergies (FAs). This article is protected by copyright. All rights reserved.

PMID: 29369340 [PubMed - as supplied by publisher]

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