Focal adhesion kinases in head and neck squamous cell carcinoma.

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Focal adhesion kinases in head and neck squamous cell carcinoma.

J Oral Pathol Med. 2018 Jan 02;:

Authors: Flores APC, Dias KB, de Campos Hildebrand L, de Oliveira MG, Lamers ML, Sant'Ana Filho M

Abstract
BACKGROUND: Focal adhesion kinase (FAK) phosphorylation contributes to the regulation of growth factors that promote cellular adhesion, mobility, and survival, being a key factor in tumor development. The objective of this study was to evaluate the immunohistochemical expression patterns of FAK and its phosphorylated forms, FAK Tyr-576 and FAK Tyr-925, in head and neck squamous cell carcinoma and non-neoplastic adjacent epithelial tissue.
METHODS: The percentage of immunohistochemistry stained cells and its correlation with clinicopathological variables and prognosis were determined using samples from 54 patients.
RESULTS: FAK, FAK Tyr-576, and FAK Tyr-925 overexpression was observed in tumor zones and non-neoplastic adjacent epithelial tissue. FAK Tyr-576 immunostaining showed a relationship with tumor clinicopathological parameters. Moreover, positive immunostaining of FAK Tyr-576 in non-neoplastic adjacent epithelial tissue was associated with patients prognoses.
CONCLUSIONS: Increased expression of FAK Tyr-576 could enable identifcation of tumors with a more aggressive behavior and epithelial alterations before the appearance of clinical or histological manifestations. This article is protected by copyright. All rights reserved.

PMID: 29292531 [PubMed - as supplied by publisher]

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