Genetic Variations of COL4A1 gene and Intracerebral Hemorrhage risk: A case-control Study in Chinese Han Population.

Genetic Variations of COL4A1 gene and Intracerebral Hemorrhage risk: A case-control Study in Chinese Han Population.

World Neurosurg. 2018 Jan 19;:

Authors: Lin S, Xia C, He S, Yang J, Li H, Zheng J, Liu M, You C

Abstract
OBJECTIVE: To investigate the association between single nucleotide polymorphisms (SNPs) or Haplotypes of COL4A1 gene and the risk of intracerebral hemorrhage (ICH).
METHODS: We conducted a case-control study which included 181 Chinese Han population patients with hypertensive ICH and 197 hypertension patients without ICH. Genomic DNA was extracted by DNA extraction kit, and the six SNPs genotyping of COL4A1 gene were detected through MassARRAY Analyzer. Unphased 3.1.4 and SPSS 19.0 were employed to analyze the association between alleles, genotypes, and haplotypes of COL4A1 gene and the risk of ICH.
RESULTS: Compared to control group, patients in ICH group were significantly younger. There were no differences in gender, diabetes, hyperlipidemia, current smoking and alcohol consumption between two groups. Our association analysis showed that rs3742207 A allele, rs11069830 A allele and rs679505 A allele were association factors of the risks of ICH; rs11069830 AA genotype, rs544012 AC genotype and rs679505 AA genotype were association factors of the risk of ICH; AA haplotype (rs3742207-rs11069830) was an association factor of the risk of ICH. After adjusting age and gender by multivariate logistic regression, rs544012 AC genotype and rs679505 AA genotype were independently associated with the risk of ICH.
CONCLUSIONS: Our study firstly showed that rs544012 AC genotype and rs679505 AA genotype were independently associated with the risk of ICH in Chinese Han population; AA haplotype (rs3742207-rs11069830) in COL4A1 gene may be related to the risk of ICH in Chinese Han population; these conclusions needed further confirmation in future studies with larger samples.

PMID: 29360590 [PubMed - as supplied by publisher]

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