Improvement of endothelial function by pitavastatin: a meta-analysis.

Improvement of endothelial function by pitavastatin: a meta-analysis.

Expert Opin Pharmacother. 2018 Jan 15;:

Authors: Katsiki N, Reiner Ž, Tedeschi Reiner E, Al-Rasadi K, Pirro M, Mikhailidis DP, Sahebkar A

Abstract
OBJECTIVE: Dyslipidemia is commonly associated with endothelial dysfunction and increased cardiovascular risk. Pitavastatin has been shown to reduce total and low-density lipoprotein cholesterol, to increase high-density lipoprotein (HDL)-cholesterol and improve HDL function. Furthermore, several trials explored its effects on flow-mediated dilation (FMD), as an index of endothelial function. The authors evaluated the effect of pitavastatin therapy on FMD.
METHODS: The authors performed a systematic review and meta-analysis of all clinical trials exploring the impact of pitavastatin on FMD. The search included PubMed-Medline, Scopus, ISI Web of Knowledge and Google Scholar databases. Quantitative data synthesis was performed using a random-effects model, with weighted mean difference (WMD) and 95% confidence interval (CI) as summary statistics.
RESULTS: Six eligible studies comprising 7 treatment arms were selected for this meta-analysis. Overall, WMD was significant for the effect of pitavastatin on FMD (2.45%, 95% CI: 1.31, 3.60, p<0.001) and the effect size was robust in the leave-one-out sensitivity analysis.
CONCLUSION: This meta-analysis of all available clinical trials revealed a significant increase of FMD induced by pitavastatin.

PMID: 29334477 [PubMed - as supplied by publisher]

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