Oral Verrucous Carcinoma: Ten Year Experience from a Tertiary Care Hospital in India.

Oral Verrucous Carcinoma: Ten Year Experience from a Tertiary Care Hospital in India.

Indian J Med Paediatr Oncol. 2017 Oct-Dec;38(4):452-455

Authors: Franklyn J, Janakiraman R, Tirkey AJ, Thankachan C, Muthusami J

Abstract
Background: Verrucous carcinoma of the oral cavity (OVC) is an uncommon variant of oral squamous cell carcinoma (OSCC). The clinical presentation and surgical outcomes of OVC are unique; however, the management protocols for OVC are largely extrapolated from OSCC.
Objectives: The aim is to study the clinical, histopathological demographics, and outcome of OVC at a tertiary care referral hospital in South India. To study the need for lymph node dissection and the role of adjuvant therapy for close resection margins.
Materials and Methods: A retrospective review of all patients diagnosed to have OVC between January 2005 and April 2015 was undertaken. Data were collected from hospital records and telephonic interview when possible.
Results: Thirty patients were diagnosed to have OVC. The most common site of the presentation was the buccal mucosa. Twenty-three patients had wide local excision of the primary tumor and seven patients had neck dissection as well. None of the patients who underwent neck dissection had node-positive disease pathologically. The margins were considered close in nine patients, only one of these patients received adjuvant radiation therapy; despite among the patients with close resection margins, there was no recurrence or disease-related mortality. Among the thirty patients, there was only one patient who had recurred locally and there was no disease associated mortality.
Conclusions: OVC is a unique variant of OSCC which has a good prognosis. Routine lymphadenectomy can be avoided.

PMID: 29333011 [PubMed]

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