Pharmacokinetic drug evaluation of daclizumab for the treatment of relapsing-remitting multiple sclerosis.

Pharmacokinetic drug evaluation of daclizumab for the treatment of relapsing-remitting multiple sclerosis.

Expert Opin Drug Metab Toxicol. 2018 Jan 24;:

Authors: Patti F, Chisari CG, D'Amico E, Zappia M

Abstract
INTRODUCTION: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. Despite the availability of several disease-modifying therapies for relapsing MS, there is a need for highly efficacious targeted therapy with a favorable benefit-risk profile and a high level of treatment adherence. Daclizumab is a humanized monoclonal antibody directed against CD25, the α subunit of the high-affinity interleukin 2 (IL-2) receptor, that reversibly modulates IL-2 signaling. Areas covered: Daclizumab blocks the activation and expansion of autoreactive T cells that plays a role in the immune pathogenesis of MS. As its modulatory effects on the immune system, daclizumab's potential for use in MS was tested extensively showing a high efficacy in reducing relapse rate, disability progression, and the number and volume of gadolinium-enhancing lesions on brain magnetic resonance imaging. Moreover, phase II and III trials showed a favorable pharmacokinetic (PK) profile with slow clearance, linear pharmacokinetics at doses above 100 mg and high subcutaneous bioavailability, not influenced by age sex or other clinical parameters. Expert opinion: Among the new emerging drugs for MS, daclizumab also thanks to a favorable PK profile, may represent an interesting and promising therapeutic option in the wide MS therapies armamentarium.

PMID: 29363337 [PubMed - as supplied by publisher]

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