Science to Practice: Will Gadolinium Chelates Be Replaced by Iron Chelates in MR Imaging?

Science to Practice: Will Gadolinium Chelates Be Replaced by Iron Chelates in MR Imaging?

Radiology. 2018 Feb;286(2):409-411

Authors: Tweedle MF

Abstract
Boehm-Sturm et al ( 1 ) pose a possible paradigm shift in magnetic resonance (MR) imaging: the substitution of iron chelates for gadolinium chelates as paramagnetic contrast agents. The advent of nephrogenic systemic fibrosis challenges the wide-spread perception that gadolinium is benign, and that all gadolinium-based contrast agents (GBCAs) are identical. Long-term gadolinium retention in patients with normal renal function is now a disturbing fact. Unlike gadolinium, iron is an endogenous metal with a tightly regulated transport and storage mechanism. The question the article raises is therefore a compelling one.

PMID: 29356647 [PubMed - in process]

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