Bone Metabolic Markers in the Clinical Assessment of Patients with Superior Semicircular Canal Dehiscence Treated with Middle Fossa Craniotomy.

Bone Metabolic Markers in the Clinical Assessment of Patients with Superior Semicircular Canal Dehiscence Treated with Middle Fossa Craniotomy.

World Neurosurg. 2018 Feb 13;:

Authors: Nguyen T, Lagman C, Sheppard JP, Duong C, Ong V, Poon J, Alkhalid Y, Azzam D, Romiyo P, Prashant GN, Gopen Q, Yang I

Abstract
BACKGROUND: Superior semicircular canal dehiscence (SSCD) is a bony defect in the osseous shell of the petrous temporal bone. The pathophysiological association between osteoporosis and SSCD remains poorly understood. We aim to investigate the relationships between serum calcium, 25-hydroxyvitamin D, and thyroid stimulating hormone levels, and symptoms in adult patients with SSCD treated through a middle fossa craniotomy.
METHODS: Patient demographics and clinical parameters were collected. Point-biserial correlation analysis was performed to investigate the relationship of bone markers with symptom outcomes. Rates of clinical symptoms were compared before and after surgery using McNemar's tests for paired comparisons of binary measures.
RESULTS: A total of 99 patients (64 females and 35 males; average age 52 years; 118 surgeries) were included. The level of serum calcium was correlated with the need for a second surgery (rpb = -0.35, P = .001). Patients supplemented with calcium post-operatively was negatively correlated with improvements in dizziness (rpb = -0.355, P =0.01). The level of 25-hydroxyvitamin D was correlated with pre-operative hyperacusis (rpb = -0.98, P = .02) and correlated with post-operative autophony (rpb = 0.96, P = .04). Patients supplemented with vitamin D post-operatively showed a positive correlation with hearing decline (rpb = 0.037, P = 0.04) The level of thyroid stimulating hormone was correlated with pre-operative autophony, amplification, and tinnitus (rpb = -0.71, rpb = -0.75, rpb = -0.70, P < .001).
CONCLUSIONS: Bone metabolic markers may be important in the clinical assessment of SSCD patients and could be potential targets for symptom management.

PMID: 29452318 [PubMed - as supplied by publisher]

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