Cellular Stress Associated with Aneuploidy

Publication date: 26 February 2018
Source:Developmental Cell, Volume 44, Issue 4
Author(s): Jin Zhu, Hung-Ji Tsai, Molly R. Gordon, Rong Li
Aneuploidy, chromosome stoichiometry that deviates from exact multiples of the haploid compliment of an organism, exists in eukaryotic microbes, several normal human tissues, and the majority of solid tumors. Here, we review the current understanding about the cellular stress states that may result from aneuploidy. The topics of aneuploidy-induced proteotoxic, metabolic, replication, and mitotic stress are assessed in the context of the gene dosage imbalance observed in aneuploid cells. We also highlight emerging findings related to the downstream effects of aneuploidy-induced cellular stress on the immune surveillance against aneuploid cells.

Teaser

Aneuploidy refers to chromosome stoichiometry deviating from exact multiples of the haploid compliment of an organism. Zhu et al. review our current understanding of the cellular stress states that may result from aneuploidy, including proteotoxic, metabolic, replication, and mitotic stress. They also discuss immune surveillance against aneuploid cells.


http://ift.tt/2sYjtJg