[Comparative sub-population analysis of exosomes from blood plasma of cancer patients].

[Comparative sub-population analysis of exosomes from blood plasma of cancer patients].

Biomed Khim. 2018 Jan;64(1):110-114

Authors: Tamkovich SN, Yunusova NV, Somov AK, Kakurina GV, Kolegova ES, Tugurova EA, Laktionov PP, Kondakova IV

Abstract
To increase the sensitivity and specificity of the developed methods for diagnosis of oncological diseases using exosomes of blood, a stage of pre-selection of tumor exosomes from a common pool of circulating microvesicles is required. In the present work, universal proteins have been identified, their expression has been increased in the exosomes of patients with colorectal cancer, head and neck squamous cell carcinomas, and lung cancer. The use of antibodies against major exosomal proteins will further develop a simple and high-performance method of affinity isolation of tumor exosomes.

PMID: 29460840 [PubMed - in process]

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