Perineural Invasion in Head and Neck Cancer.

Perineural Invasion in Head and Neck Cancer.

J Dent Res. 2018 Feb 01;:22034518756297

Authors: Schmitd LB, Scanlon CS, D'Silva NJ

Abstract
Perineural invasion (PNI) is a mechanism of tumor dissemination that can provide a challenge to tumor eradication and that is correlated with poor survival. Squamous cell carcinoma, the most common type of head and neck cancer, has a high prevalence of PNI. This review provides an overview of clinical studies on the outcomes and factors associated with PNI in head and neck cancer and on findings on cancer-nerve crosstalk.

PMID: 29443582 [PubMed - as supplied by publisher]

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