[Radiation therapy in inflammatory breast cancer].

[Radiation therapy in inflammatory breast cancer].

Bull Cancer. 2018 Feb 20;:

Authors: Jardel P, Alami Z, Vignot S, Creisson A, Danhier S, Geffrelot J, Levy C, Kammerer E, Lebrun JF, Thariat J

Abstract
BACKGROUND: Inflammatory breast cancer accounts for 1-5% of all breast cancers. It is associated with a poor prognosis, because of an increased risk to develop metastases in comparison with all breast malignancies. The treatment is multimodal. We have evaluated the role of radiotherapy: indications, techniques and impact for local control and overall survival.
METHOD: The series of the literature with more than 40 patients irradiated for inflammatory breast cancer published since 1995 were analyzed.
RESULTS: Chemotherapy was always delivered first. Adjuvant radiotherapy was associated with local control and overall survival at 10 years of 63-92% and 51-64 respectively. Without surgery, local control was 65% and overal survival 38% at 10years. Results of concomitant radiochemotherapy were reported: the studies were heterogenous. Modalities of radiotherapy were detailed with respect to dose and fractionation, target-volumes and technical considerations (including bolus).
CONCLUSION: The multimodal strategy comprises systematically radiotherapy with an evaluation of tumor response to maximise resecability.

PMID: 29475596 [PubMed - as supplied by publisher]

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