Sarcomas of the sinonasal tract.

Sarcomas of the sinonasal tract.

Head Neck. 2018 Feb 14;:

Authors: Kauke M, Safi AF, Grandoch A, Nickenig HJ, Zöller J, Kreppel M

Abstract
BACKGROUND: Sinonasal sarcomas are rare and heterogeneous in nature. Continuously collecting data influencing the prognosis is fundamental for optimizing therapeutic assessment of this highly destructive neoplasm.
METHODS: We conducted a single-institution retrospective cohort study considering 27 patients with sinonasal sarcoma.
RESULTS: The overall survival (OS) rates for 1 year and 5 years were calculated as 74% and 36%, respectively. Extent of the primary tumor (P = .010), nodal spread (P = .009), and age (P = .004) significantly reduced the OS. Disease-free survival (DFS) was significantly reduced by age (P = .003), extent of the primary (P = .006), nodal (P = .004), and hematogenous (P = .048) spread. Multimodal therapy including surgery improved the OS and DFS rates (P < .05).
CONCLUSION: Prognosis is poor due to late disease recognition. However, multimodal therapeutic regimens, including surgery, may improve the outcome.

PMID: 29443431 [PubMed - as supplied by publisher]

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