Stability of Cefazolin in Polyisoprene Elastomeric Infusion Devices

Publication date: Available online 26 February 2018
Source:Clinical Therapeutics
Author(s): Rahul P. Patel, Jilson Jacob, Mohammed Sedeeq, Long Chiau Ming, Troy Wanandy, Syed Tabish R. Zaidi, Gregory M. Peterson
PurposeThe aim was to investigate the stability of cefazolin in elastomeric infusion devices.MethodsElastomeric devices (Infusor LV) that contain cefazolin (3 g/240 mL and 6 g/240 mL) were prepared and stored at 4°C for 72 hours and then at 35°C for 12 hours, followed by 25°C for 12 hours. An aliquot was withdrawn at predefined time points and analyzed for the concentration of cefazolin. Samples were also assessed for changes in pH, solution color, and particle content.FindingsCefazolin retained acceptable chemical and physical stability over the studied storage period and conditions.ImplicationsThese findings will allow the administration of cefazolin by the Infusor LV elastomeric device in the outpatient and remote settings.



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