The first clinical implementation of real-time image-guided adaptive radiotherapy using a standard linear accelerator

Publication date: Available online 7 February 2018
Source:Radiotherapy and Oncology
Author(s): Paul J. Keall, Doan Trang Nguyen, Ricky O'Brien, Vincent Caillet, Emily Hewson, Per Rugaard Poulsen, Regina Bromley, Linda Bell, Thomas Eade, Andrew Kneebone, Jarad Martin, Jeremy T. Booth
PurposeUntil now, real-time image guided adaptive radiation therapy (IGART) has been the domain of dedicated cancer radiotherapy systems. The purpose of this study was to clinically implement and investigate real-time IGART using a standard linear accelerator.Materials/methodsWe developed and implemented two real-time technologies for standard linear accelerators: (1) Kilovoltage Intrafraction Monitoring (KIM) that finds the target and (2) multileaf collimator (MLC) tracking that aligns the radiation beam to the target. Eight prostate SABR patients were treated with this real-time IGART technology. The feasibility, geometric accuracy and the dosimetric fidelity were measured.ResultsThirty-nine out of forty fractions with real-time IGART were successful (95% confidence interval 87–100%). The geometric accuracy of the KIM system was −0.1 ± 0.4, 0.2 ± 0.2 and −0.1 ± 0.6 mm in the LR, SI and AP directions, respectively. The dose reconstruction showed that real-time IGART more closely reproduced the planned dose than that without IGART. For the largest motion fraction, with real-time IGART 100% of the CTV received the prescribed dose; without real-time IGART only 95% of the CTV would have received the prescribed dose.ConclusionThe clinical implementation of real-time image-guided adaptive radiotherapy on a standard linear accelerator using KIM and MLC tracking is feasible. This achievement paves the way for real-time IGART to be a mainstream treatment option.



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