Σφακιανάκης Αλέξανδρος
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Δευτέρα 26 Μαρτίου 2018

A Golgi Lipid Signaling Pathway Controls Apical Golgi Distribution and Cell Polarity during Neurogenesis

Publication date: 26 March 2018
Source:Developmental Cell, Volume 44, Issue 6
Author(s): Zhigang Xie, Seong Kwon Hur, Liang Zhao, Charles S. Abrams, Vytas A. Bankaitis
Phosphatidylinositol (PtdIns) transfer proteins (PITPs) stimulate PtdIns-4-P synthesis and signaling in eukaryotic cells, but to what biological outcomes such signaling circuits are coupled remains unclear. Herein, we show that two highly related StART-like PITPs, PITPNA and PITPNB, act in a redundant fashion to support development of the embryonic mammalian neocortex. PITPNA/PITPNB do so by driving PtdIns-4-P-dependent recruitment of GOLPH3, and likely ceramide transfer protein (CERT), to Golgi membranes with GOLPH3 recruitment serving to promote MYO18A- and F-actin-directed loading of the Golgi network to apical processes of neural stem cells (NSCs). We propose the primary role for PITP/PtdIns-4-P/GOLPH3/CERT signaling in NSC Golgi is not in regulating bulk membrane trafficking but in optimizing apically directed membrane trafficking and/or apical membrane signaling during neurogenesis.

Graphical abstract

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Teaser

Xie et al. describe a cell-autonomous phosphatidylinositol-4-phosphate-dependent pathway essential for neocortex development that regulates neural stem cell function by loading the Golgi network into the cellular apical compartment. The circuit involves two lipid transfer proteins (PITPNA/PITPNB) that potentiate phosphatidylinositol-4-phosphate synthesis, and GOLPH3 and CERT as effectors of phosphatidylinositol-4-phosphate signaling.


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