A short synthesis of Dronedarone

Publication date: Available online 28 March 2018
Source:Bioorganic & Medicinal Chemistry
Author(s): Barbara Piotrkowska, Sven Nerdinger, Erwin Schreiner, Lovro Selič, Piotr P. Graczyk
A modification of the Nenitzescu reaction was used to obtain Dronedarone from quinonimine 15 and 1,3-diketone 18 (R=CH2CH2CH2NBu2) in a two-stage process in almost 55% overall yield. Our results represent significant improvement over other state-of-the-art methods as no extra steps for the decoration of the benzofuran core are required.

Graphical abstract

https://ift.tt/2J6OMp6