Publication date: Available online 9 March 2018
Source:Autoimmunity Reviews
Author(s): Marta Consuegra-Fernández, Feng Lin, David A. Fox, Francisco Lozano
CD6 is a cell surface glycoprotein expressed by most T cells and a subset of B cells that has incompletely-defined roles in regulation of lymphocyte development, selection, activation and differentiation. The two main known mammalian CD6 ligands, CD166/ALCAM and the very recently reported CD318, are widely expressed by both immune cells and a wide range of other cell types, including various epithelial and mesenchymal cell types, as well as many neoplasms. Moreover, CD6 is also a receptor for several pathogen- and damage-associated molecular patterns. Further layers of complexity of CD6 function are implied by the existence of multiple CD6 isoforms generated by alternative splicing of CD6 transcripts and soluble forms of CD6 released by proteases from the lymphocyte surface. Multiple lines of evidence are now emerging to implicate CD6 and its ligands in the pathogenesis and potentially the treatment of human autoimmune diseases, such as multiple sclerosis and psoriasis. CD6 is an important multiple sclerosis risk gene, and mice genetically deficient in CD6 or CD318, or treated with antibodies or chimerical proteins that interfere with CD6-ligand interactions, are protected from experimental allergic encephalomyelitis, a mouse model of multiple sclerosis. CD6 deficient mice also show reduced TH17 differentiation and protection from disease in a moue model of psoriasis, providing a foundation for successful clinical trials of an anti-CD6 monoclonal antibody (Itolizumab) in psoriasis. Here we review current knowledge about CD6 and its ligands, and consider its potential value as a therapeutic target in a range of immune-mediated disorders.
http://ift.tt/2p2vaJJ
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00306932607174
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- Patch Testing in Gastrointestinal Diseases – A Sys...
- Contact hypersensitivity in rosacea – a report on ...
- Reply to: Kubiak K. And al. Endosymbiosis and its ...
- The iris signal: blue periphery, tan collaret and ...
- 5 alpha-reductase inhibitor treatment for frontal ...
- Rapid fully automatic segmentation of subcortical ...
- Estimating fiber orientation distribution from dif...
- Focal immune-related pancreatitis occurring after ...
- Immune checkpoint therapy in proteinuric kidney di...
- (Meth)acrylate allergy: frequently missed?
- (Meth)acrylate allergy: frequently missed?
- Mutilating male genital Crohn's without gastrointe...
- Long-Term Optimization of Outcomes With Flexible A...
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- Blunt cannula subcision is more effective than Nok...
- Clinical evaluation of simultaneously applied mono...
- Antiaging and antioxidant effects of topical autop...
- Blunt cannula subcision is more effective than Nok...
- Clinical evaluation of simultaneously applied mono...
- Antiaging and antioxidant effects of topical autop...
- Design and characterization of silicone micromater...
- Meta-Analysis: Contrast-Enhanced Ultrasound Versus...
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- Slip transfer across γ-TiAl lamellae in tension
- Fatigue driven matrix crack propagation in laminat...
- Effect of particle shape and size on the morpholog...
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- Safe removal of gloves from contact precautions: T...
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- A Futile Battle? Protein Quality Control and the S...
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