[Diffuse large B-cell lymphoma complicated with drug-induced vasculitis during administration of pegfilgrastim].

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[Diffuse large B-cell lymphoma complicated with drug-induced vasculitis during administration of pegfilgrastim].

Rinsho Ketsueki. 2017;58(11):2238-2242

Authors: Ito Y, Noda K, Aiba K, Yano S, Fujii T

Abstract
A 59-year-old female with diffuse large B-cell lymphoma was treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) regimen. In addition, we administered pegfilgrastim for treating chemotherapy-induced febrile neutropenia. She complained of fever and neck and chest pain a few days after pegfilgrastim administration during the third and fourth courses of R-CHOP. Radiological imaging revealed an inflammation of large vessels, which led to the diagnosis of drug-associated vasculitis. We confirmed that vasculitis observed in this case was caused by pegfilgrastim administration because similar symptoms appeared with both injections of pegfilgrastim.

PMID: 29212975 [PubMed - indexed for MEDLINE]

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