Immunohistochemical investigation of predictors of response or aggressiveness of bowen disease after photodynamic therapy

Publication date: June 2018
Source:Photodiagnosis and Photodynamic Therapy, Volume 22
Author(s): M. Fernández-Guarino, M.L. González Morales, Israel Bernal, A.I. Sánchez Adrada, Sandra Pierri Ugia, J. Barrio Garde
BackgroundPhotodynamic therapy (PDT) is a good option for the treatment of Bowen's disease (BD). However, BD occasionally can progress into a squamous cell carcinoma (SCC) after PDT.ObjectiveFind predictors of aggressiveness of BD after PDTMethodsTwo biopsies of patients with BD treated with PDT with progression to SCC within three months were selected for immunohistochemical (IHC) studies. Conventional PDT was applied. IHC analysis was performed together with hematoxylin-eosin in the biopsies prior to and after treatment with PDT.ResultsAmong the IHC markers studied, none showed different expressions between pre-treatment and post-treatment biopsies except for HSP70ConclusionsThe expression of Hsp70 in BD may predict future aggressive behaviour in BD when treated with PDT. Nevertheless, due to the small number of biopsies studied, further investigations are required to draw conclusions.



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