Publication date: Available online 12 March 2018
Source:The Journal of Steroid Biochemistry and Molecular Biology
Author(s): Shiho Fujita, Toru Hasegawa, Yuki Nishiyama, Satoshi Fujisawa, Yasuhiro Nakano, Takahiro Nada, Nahoko Iwata, Yasuhiko Kamada, Hisashi Masuyama, Fumio Otsuka
The involvement of orexins in reproductive function has been gradually uncovered. However, the functional role of orexins in ovarian steroidogenesis remains unclear. In the present study, we investigated the effects of orexin A on ovarian steroidogenesis by using rat primary granulosa cells that express both OX1 and OX2 receptors for orexins. Treatment with orexin A enhanced progesterone, but not estradiol, biosynthesis induced by FSH, whereas it did not affect basal levels of progesterone or estradiol. In accordance with the effects on steroidogenesis, orexin A increased the mRNA levels of progesterogenic enzymes, including StAR, P450scc and 3βHSD, but not P450arom, and cellular cAMP synthesis induced by FSH. Under the condition of blockage of endogenous BMP actions by noggin or BMP-signaling inhibitors, orexin A failed to increase levels of progesterone synthesis induced by FSH treatment, suggesting that endogenous BMP activity in granulosa cells might be involved in the enhancement of progesterone synthesis by orexin A. Treatment with orexin A impaired Smad1/5/9 activation as well as Id-1 mRNA expression stimulated by BMP-6 and BMP-7, the latter of which was reversed by treatment with an OX1 antagonist. It was also found that orexin A suppressed the mRNA expression of both type-I and -II receptors for BMPs and increased that of inhibitory Smad6 and Smad7 in granulosa cells. On the other hand, treatments with BMP-6 and -7 suppressed the expression of OX1 and OX2. Collectively, the results indicated that orexin A enhances FSH-induced progesterone production, at least in part, by downregulating BMP signaling in granulosa cells. Thus, a new role of orexin A in facilitating progesterone synthesis and functional interaction between the orexin and BMP systems in granulosa cells were revealed.
http://ift.tt/2palrRD
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
Αρχειοθήκη ιστολογίου
-
►
2023
(391)
- ► Φεβρουαρίου (200)
- ► Ιανουαρίου (191)
-
►
2022
(2843)
- ► Δεκεμβρίου (161)
- ► Σεπτεμβρίου (219)
- ► Φεβρουαρίου (264)
- ► Ιανουαρίου (280)
-
►
2021
(5625)
- ► Δεκεμβρίου (231)
- ► Σεπτεμβρίου (345)
- ► Φεβρουαρίου (620)
-
►
2020
(2065)
- ► Δεκεμβρίου (535)
- ► Σεπτεμβρίου (222)
- ► Φεβρουαρίου (28)
-
►
2019
(9608)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3791)
- ► Ιανουαρίου (3737)
-
▼
2018
(69720)
- ► Δεκεμβρίου (3507)
- ► Σεπτεμβρίου (3851)
-
▼
Μαρτίου
(9878)
-
▼
Μαρ 13
(324)
- Simple solution to prevent postoperative bleeding ...
- Table of Contents
- I pledge to prescribe ethically
- Information for Readers
- Comorbidities in rosacea: A systematic review and ...
- JAAD Case Reports Article List
- Journal Based CME Instructions and Information
- Alopecia areata is a medical disease
- Analysis of the patient experience measure
- Editorial Board
- Answers to CME examination
- Topical calcipotriol before ablative fractional la...
- CME examination
- Rituximab as first-line adjuvant therapy for pemph...
- Recommendations for improving the patient experien...
- CME examination
- Prescribing to save patients money: Ethical consid...
- Answers to CME examination
- All-cause mortality in patients with basal and squ...
- Omalizumab response in patients with chronic idiop...
- Ultrasound Molecular Imaging of Atherosclerosis Us...
- HDR Salvage Brachytherapy: Multiple Hypothesis Tes...
- Close margin <2mm is not associated with higher ri...
- Vascular liver lesions: contemporary views on long...
- Cisplatin suppresses proliferation, migration and ...
- An in vivo evaluation of microbial diversity befor...
- Superficial resection combined with photodynamic t...
- The response surface methodology speeds up the sea...
- Efficacy of Er Cr: YSGG laser therapy at different...
- Photonic technology for the treatments of venous a...
- CME examination
- Prescribing to save patients money: Ethical consid...
- I pledge to prescribe ethically
- March iotaderma (#289)
- Alopecia areata is a medical disease
- Indentured servitude or junior faculty extension o...
- Iotaderma #290
- Recommendations for improving the patient experien...
- Editorial Board
- CME examination
- Simple solution to prevent postoperative bleeding ...
- Journal Based CME Instructions and Information
- Dermatology Calendar
- Answers to CME examination
- JAAD Case Reports Article List
- Correction of “sandwiching phenomenon” following h...
- Billing of botulinum toxin for hyperhidrosis: Ethi...
- Tissue control of androgen action: The ups and dow...
- Editorial Board
- The role of androgen receptors in atherosclerosis
- Role of the androgen receptor in the central nervo...
- Development of selective androgen receptor modulat...
- Cancer Trials Ireland (ICORG) 06-34: A multi-centr...
- A prospective cohort study of hepatic toxicity aft...
- Doing the right thing: Quality in radiotherapy, a ...
- Seasonal variations in cellular expression of neur...
- Icarus, Blood Pressure, and the Dangers of Flying ...
- Dietary Patterns to Reduce Weight and Optimize Car...
- Efficacy and Safety of the Use of Non-Vitamin K An...
- Non-Vitamin K Antagonist Preferred in Patients Wit...
- Effects of Bariatric Surgery in Obese Patients Wit...
- Integrative Omics: Harnessing the Proteome to Maxi...
- Exercise Therapy and Cardiovascular Toxicity in Ca...
- Alternating Bundle-Branch Block: What Is the Mecha...
- Widening Racial Differences in Risks for Coronary ...
- Letter by Tsuda Regarding Article, "A Novel [alpha...
- Letter by Jin-shan and Xue-bin Regarding Article, ...
- Response by Aubdool et al to Letters Regarding Art...
- Letter by Mutlu and Budinger Regarding Article, "P...
- Letter by Jordan and Biaggioni Regarding Article, ...
- Letter by Li et al Regarding Article, "Particulate...
- Response by Li et al to Letters Regarding Article,...
- Myeloid derived-suppressor cells: their role in ca...
- Evidence of transcranial direct current stimulatio...
- Psychological Treatment
- Multizentrische Analyse des Nutzerverhaltens von C...
- Effects of nasal septum perforation repair on nasa...
- Clinical features of nasal and sinonasal inverted ...
- Cover Image
- Author Guidelines
- Issue Information
- Thyroid Disease Around the World
- Asthma-Related Mortality in the United States of A...
- Sunscreen sun protection factor (SPF): Is higher b...
- Ixekizumab treatment shows a neutral impact on car...
- Temporal dynamics of gut microbiota in triclocarba...
- Prevalence of C-shaped canal system in mandibular ...
- Quick synthesis of 2-propanol derived fluorescent ...
- Impact of database quality in knowledge-based trea...
- Manipulation of VEGF-induced angiogenesis by 2-N, ...
- Targeting tumor hypoxia with stimulus-responsive n...
- Unilateral Cleft Lip Rhinoplasty
- Histone Deacetylases 1 and 2 Regulate Microglia Fu...
- Biomaterial scaffolds for non-invasive focal hyper...
- Systemic study of solvent-assisted active loading ...
- “Stepwise Extraction” strategy-based injectable bi...
- Cargo-free particles of ammonio methacrylate copol...
- Harnessing biochemical and structural cues for ten...
- Hydrotalcite monolayer toward high performance syn...
- Editorial Board
-
▼
Μαρ 13
(324)
- ► Φεβρουαρίου (8116)
- ► Ιανουαρίου (7758)
-
►
2017
(111579)
- ► Δεκεμβρίου (7718)
- ► Σεπτεμβρίου (7549)
- ► Φεβρουαρίου (10753)
- ► Ιανουαρίου (10529)
-
►
2016
(16402)
- ► Δεκεμβρίου (7478)
- ► Φεβρουαρίου (900)
- ► Ιανουαρίου (1250)
! # Ola via Alexandros G.Sfakianakis on Inoreader
Η λίστα ιστολογίων μου
Τρίτη 13 Μαρτίου 2018
Interaction between orexin A and bone morphogenetic protein system on progesterone biosynthesis by rat granulosa cells
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Αρχειοθήκη ιστολογίου
-
►
2023
(391)
- ► Φεβρουαρίου (200)
- ► Ιανουαρίου (191)
-
►
2022
(2843)
- ► Δεκεμβρίου (161)
- ► Σεπτεμβρίου (219)
- ► Φεβρουαρίου (264)
- ► Ιανουαρίου (280)
-
►
2021
(5625)
- ► Δεκεμβρίου (231)
- ► Σεπτεμβρίου (345)
- ► Φεβρουαρίου (620)
-
►
2020
(2065)
- ► Δεκεμβρίου (535)
- ► Σεπτεμβρίου (222)
- ► Φεβρουαρίου (28)
-
►
2019
(9608)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3791)
- ► Ιανουαρίου (3737)
-
▼
2018
(69720)
- ► Δεκεμβρίου (3507)
- ► Σεπτεμβρίου (3851)
-
▼
Μαρτίου
(9878)
-
▼
Μαρ 13
(324)
- Simple solution to prevent postoperative bleeding ...
- Table of Contents
- I pledge to prescribe ethically
- Information for Readers
- Comorbidities in rosacea: A systematic review and ...
- JAAD Case Reports Article List
- Journal Based CME Instructions and Information
- Alopecia areata is a medical disease
- Analysis of the patient experience measure
- Editorial Board
- Answers to CME examination
- Topical calcipotriol before ablative fractional la...
- CME examination
- Rituximab as first-line adjuvant therapy for pemph...
- Recommendations for improving the patient experien...
- CME examination
- Prescribing to save patients money: Ethical consid...
- Answers to CME examination
- All-cause mortality in patients with basal and squ...
- Omalizumab response in patients with chronic idiop...
- Ultrasound Molecular Imaging of Atherosclerosis Us...
- HDR Salvage Brachytherapy: Multiple Hypothesis Tes...
- Close margin <2mm is not associated with higher ri...
- Vascular liver lesions: contemporary views on long...
- Cisplatin suppresses proliferation, migration and ...
- An in vivo evaluation of microbial diversity befor...
- Superficial resection combined with photodynamic t...
- The response surface methodology speeds up the sea...
- Efficacy of Er Cr: YSGG laser therapy at different...
- Photonic technology for the treatments of venous a...
- CME examination
- Prescribing to save patients money: Ethical consid...
- I pledge to prescribe ethically
- March iotaderma (#289)
- Alopecia areata is a medical disease
- Indentured servitude or junior faculty extension o...
- Iotaderma #290
- Recommendations for improving the patient experien...
- Editorial Board
- CME examination
- Simple solution to prevent postoperative bleeding ...
- Journal Based CME Instructions and Information
- Dermatology Calendar
- Answers to CME examination
- JAAD Case Reports Article List
- Correction of “sandwiching phenomenon” following h...
- Billing of botulinum toxin for hyperhidrosis: Ethi...
- Tissue control of androgen action: The ups and dow...
- Editorial Board
- The role of androgen receptors in atherosclerosis
- Role of the androgen receptor in the central nervo...
- Development of selective androgen receptor modulat...
- Cancer Trials Ireland (ICORG) 06-34: A multi-centr...
- A prospective cohort study of hepatic toxicity aft...
- Doing the right thing: Quality in radiotherapy, a ...
- Seasonal variations in cellular expression of neur...
- Icarus, Blood Pressure, and the Dangers of Flying ...
- Dietary Patterns to Reduce Weight and Optimize Car...
- Efficacy and Safety of the Use of Non-Vitamin K An...
- Non-Vitamin K Antagonist Preferred in Patients Wit...
- Effects of Bariatric Surgery in Obese Patients Wit...
- Integrative Omics: Harnessing the Proteome to Maxi...
- Exercise Therapy and Cardiovascular Toxicity in Ca...
- Alternating Bundle-Branch Block: What Is the Mecha...
- Widening Racial Differences in Risks for Coronary ...
- Letter by Tsuda Regarding Article, "A Novel [alpha...
- Letter by Jin-shan and Xue-bin Regarding Article, ...
- Response by Aubdool et al to Letters Regarding Art...
- Letter by Mutlu and Budinger Regarding Article, "P...
- Letter by Jordan and Biaggioni Regarding Article, ...
- Letter by Li et al Regarding Article, "Particulate...
- Response by Li et al to Letters Regarding Article,...
- Myeloid derived-suppressor cells: their role in ca...
- Evidence of transcranial direct current stimulatio...
- Psychological Treatment
- Multizentrische Analyse des Nutzerverhaltens von C...
- Effects of nasal septum perforation repair on nasa...
- Clinical features of nasal and sinonasal inverted ...
- Cover Image
- Author Guidelines
- Issue Information
- Thyroid Disease Around the World
- Asthma-Related Mortality in the United States of A...
- Sunscreen sun protection factor (SPF): Is higher b...
- Ixekizumab treatment shows a neutral impact on car...
- Temporal dynamics of gut microbiota in triclocarba...
- Prevalence of C-shaped canal system in mandibular ...
- Quick synthesis of 2-propanol derived fluorescent ...
- Impact of database quality in knowledge-based trea...
- Manipulation of VEGF-induced angiogenesis by 2-N, ...
- Targeting tumor hypoxia with stimulus-responsive n...
- Unilateral Cleft Lip Rhinoplasty
- Histone Deacetylases 1 and 2 Regulate Microglia Fu...
- Biomaterial scaffolds for non-invasive focal hyper...
- Systemic study of solvent-assisted active loading ...
- “Stepwise Extraction” strategy-based injectable bi...
- Cargo-free particles of ammonio methacrylate copol...
- Harnessing biochemical and structural cues for ten...
- Hydrotalcite monolayer toward high performance syn...
- Editorial Board
-
▼
Μαρ 13
(324)
- ► Φεβρουαρίου (8116)
- ► Ιανουαρίου (7758)
-
►
2017
(111579)
- ► Δεκεμβρίου (7718)
- ► Σεπτεμβρίου (7549)
- ► Φεβρουαρίου (10753)
- ► Ιανουαρίου (10529)
-
►
2016
(16402)
- ► Δεκεμβρίου (7478)
- ► Φεβρουαρίου (900)
- ► Ιανουαρίου (1250)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου