Molecular Cogs: Interplay between Circadian Clock and Cell Cycle

Publication date: Available online 19 February 2018
Source:Trends in Cell Biology
Author(s): Jonathan Gaucher, Emilie Montellier, Paolo Sassone-Corsi
The cell cycle and the circadian clock operate as biological oscillators whose timed functions are tightly regulated. Accumulating evidence illustrates the presence of molecular links between these two oscillators. This mutual interplay utilizes various coupling mechanisms, such as the use of common regulators. The connection between these two cyclic systems has unique interest in the context of aberrant cell proliferation since both of these oscillators are frequently misregulated in cancer cells. Further studies will provide deeper understanding of the detailed molecular connections between the cell cycle and the circadian clock and may also serve as a basis for the design of innovative therapeutic strategies.



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