Role of lipid mediators and control of lymphocyte responses in type 2 immunopathology

Publication date: Available online 2 March 2018
Source:Journal of Allergy and Clinical Immunology
Author(s): Sachin K. Samuchiwal, Joshua A. Boyce
Type 2 immunopathology is a cardinal feature of allergic diseases, and involves cooperation between adaptive immunity and innate effector responses. Virtually all cell types relevant to this pathology generate leukotriene and/or prostaglandin mediators that derive from arachidonic acid, and/or express receptors for such mediators. Recent studies highlight prominent functions for these mediators in communication between innate and adaptive immune systems, as well as amplification or suppression of type 2 effector responses. This review focuses on recent advances and insights, and highlights existing and potential therapeutic applications of drugs that target these mediators or their receptors, with a special emphasis on their regulation of the innate and adaptive lymphocytes relevant to type 2 immunopathology.



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