Trypanosoma cruzi infection of human induced pluripotent stem cell-derived cardiomyocytes: an in vitro model for drug screening for Chagas disease

Publication date: Available online 22 March 2018
Source:Microbes and Infection
Author(s): Leonardo da Silva Lara, Leonardo Andrade-Lima, Claudia Magalhães Calvet, Juliana Borsoi, Thabata Lopes Alberto Duque, Andrea Henriques-Pons, Mirian Claudia Souza Pereira, Lygia Veiga Pereira
Chagas disease, caused by Trypanosoma cruzi, is an important global public health problem which, despite partial efficacy of benznidazole (Bz) in acute phase, urgently needs an effective treatment. Cardiotoxicity is a major safety concern for conduction of more accurate preclinical drug screening platforms. Human induced pluripotent stem cells derived cardiomyocytes (hiPSC-CM) are a reliable model to study genetic and infectious cardiac alterations and may improve drug development. Herein, we introduce hiPSC-CM as a suitable model to study T. cruzi heart infection and to predict the safety and efficacy of anti-T. cruzi drugs.



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