B Lymphoblastic Leukemia Minimal Residual Disease Assessment by Flow Cytometric Analysis.

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B Lymphoblastic Leukemia Minimal Residual Disease Assessment by Flow Cytometric Analysis.

Clin Lab Med. 2017 Dec;37(4):771-785

Authors: Shaver AC, Seegmiller AC

Abstract
Among the most thoroughly evaluated modalities for assessment of minimal residual disease (MRD) in B acute lymphoblastic leukemia is multiparameter flow cytometry. Flow cytometric evaluation of MRD for B-ALL requires complete understanding of the immunophenotype of hematogones, the normal counterpart of leukemic B lymphoblasts. Assessment of multiple flow cytometry markers, in concert with each other in multidimensional histograms, is necessary to distinguish hematogones from malignant blasts. Emerging therapies targeting CD19 and other B-cell markers can disrupt the most frequently MRD assessment, requiring a revised approach as use of targeted therapies becomes widespread.

PMID: 29128068 [PubMed - indexed for MEDLINE]

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