Cerebral Microbleeds Could be Independently Associated with the Intracranial Aneurysm Rupture: A Cross-Sectional Population-Based Study.

Cerebral Microbleeds Could be Independently Associated with the Intracranial Aneurysm Rupture: A Cross-Sectional Population-Based Study.

World Neurosurg. 2018 Apr 11;:

Authors: Zhang X, Yao ZQ, Karuna T, Duan CZ, Wang XM, Li XF, Yin JH, He XY, Guo SQ, Chen YC, Liu WC

Abstract
OBJECTIVE: The article aims to determine whether the presence of cerebral microbleeds (CMBs) is independently associated with the intracranial aneurysm rupture. It also intends to identify the incubation period of CMBs related intracranial aneurysm rupture.
METHODS: A total of 1847 patients with unruptured and ruptured intracranial aneurysm from January 2010 to November 2017 were included in this cross-sectional study. Their clinical records and images, including the preoperative presence of CMBs identified by T2-weighted gradient-recalled-echo sequence on magnetic resonance imaging (MRI) were evaluated. Univariate analysis and multivariate logistic regression were done to determine which parameters are independent factors for aneurysm rupture. The incubation period of CMBs related intracranial aneurysm rupture was also evaluated.
RESULTS: CMBs confirmed by MRI were present in 142 patients, with 7.7% incidence rate (142/1847). Of the total 142 patients with CMBs, 56 patients (including 17 ruptured anrueysms) received endovascular treatment, and other 86 consecutive patients who did not receive emobilization or surgery due to various reasons were followed for 3-49 months. The incidence of CMBs related intracranial aneurysm rupture was 27.9% (24/86) during the follow-up. The incubation period of CMBs related intracranial aneurysm rupture varies from 3 to 27 months (median month, 9.5 months). Multivariate analyses showed CMBs is significantly correlated with the intracranial aneurysm rupture (OR 1.6, 95%C.I. 1.1 to 2.4, P=0.010).
CONCLUSIONS: CMBs is independently associated with the intracranial aneurysm rupture. Patient with CMBs has the increased 60% risk of aneurysm rupture than those without.

PMID: 29654957 [PubMed - as supplied by publisher]

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