Effect of in utero and lactational exposure of triazophos on reproductive system functions in male offsprings, Rattus norvegicus.

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Effect of in utero and lactational exposure of triazophos on reproductive system functions in male offsprings, Rattus norvegicus.

Drug Chem Toxicol. 2018 Apr 23;:1-7

Authors: Bhanot R, Sangha GK

Abstract
In the present study, Triazophos (TZ) was used at acceptable daily intake (ADI) to investigate the consequence of prenatal and postnatal exposure on reproductive functions in the male offsprings. Pregnant females were divided into three groups, the first group was orally gavaged with olive oil (control), the second group was administered with 0.01 mg kg-1 bw of the ADI of TZ from gestation day (GD) 1 until parturition (designated as P group) and the third group was gavaged with the same dose from GD1 to postnatal day (PND) 21 of lactation (marked as P + L group). Non-significant reduction occurred in the body weight of pups except at (PND) 35 during which body weight of P + L group pups significantly decreased. Male offsprings born to TZ exposed females showed significant changes at maturity (PND 63) in weight of liver, thyroid and testis, alterations in the levels of protein, urea, creatinine in plasma and abnormal levels of cholesterol, phospholipids and lipid peroxidation in testicular homogenate. Gonadal inhibition in TZ exposed progeny was reflected from a significant fall in sperm count, sperm motility, plasma testosterone level and histopathological alterations in testis. Hence, in utero and lactational exposure to ADI level of TZ influences testis development and functions in the male offsprings. Further investigations are suggested with germline studies of offsprings to examine the transgenerational effect of TZ exposure.

PMID: 29681207 [PubMed - as supplied by publisher]

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