How to actively treat food allergy

Purpose of review In the last years, food allergy treatment is moving away from food avoidance to interventional treatments. We review here the recent developments on immunotherapy with food allergens. Recent findings Oral immunotherapy remains the best studied form of food immunotherapy. In 2017, further evidence has been added to its efficacy. Its mechanisms of action are under scrutiny. To reduce its side effects, studies have been dedicated to the simultaneous use of biologics, in particular omalizumab. Among the other forms of food immunotherapy that are being developed, the epicutaneous application of food allergens is promising. Summary The immunologic trajectories of the development of food tolerance may be intercepted by different forms of food immunotherapy. Research efforts aim to make these therapies feasible at the clinical level. Correspondence to Valentina Pecora, MD, PhD, Allergy Department, Pediatric Hospital Bambino Gesù – Piazza di Sant'Onofrio 4, Vatican City, Rome 00100, Italy. Tel: +39 46 6859 4777; fax: +39 46 6859 2020; e-mail: valentina.pecora@opbg.net Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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