Intracranial arterial fenestration and risk of aneurysm: a systematic review and meta-analysis.

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Intracranial arterial fenestration and risk of aneurysm: a systematic review and meta-analysis.

World Neurosurg. 2018 Apr 24;:

Authors: Guo X, Gao L, Shi Z, Liu D, Wang Y, Sun Z, Chen Y, Chen W, Yang Y

Abstract
OBJECTIVE: Previous studies are inconsistent regarding risk for intracranial aneurysm related to intracranial arterial fenestration. We conducted a meta-analysis to examine the association between intracranial arterial fenestration and risk of aneurysm.
METHODS: We performed a systematic review of PubMed and Embase through August 2017 for potentially relevant articles that tested the association between intracranial arterial fenestration and aneurysm. Summary odds ratios (OR) with 95% confidence intervals (CI) were pooled using a random effects model.
RESULTS: Of 446 articles found, 7 were selected for the meta-analysis. Pooled OR revealed an increased risk of aneurysm due to fenestration of 1.50 (95% CI: 0.61-3.71; P = 0.38). Subgroup analyses based on the population presenting with various indications suggested that pooled OR indicated a significant increase in risk for aneurysm of 2.43 (95% CI: 1.04-5.69; P = 0.04).
CONCLUSIONS: The findings of the present meta-analysis indicate that intracranial arterial fenestration may be associated with increased risk for aneurysm formation.

PMID: 29702312 [PubMed - as supplied by publisher]

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