Low-grade glioma of the neurohypophysis: Clinical characteristics and surgical outcomes.
World Neurosurg. 2018 Apr 03;:
Authors: Nagata Y, Inoshita N, Fukuhara N, Yamaguchi-Okada M, Nishioka H, Yamada S
Abstract
BACKGROUND: Low-grade glioma (LGG) of the neurohypophysis is an extremely rare tumor arising from the pituicytes of the posterior pituitary or the infundibulum. The preoperative imaging findings of these tumors mimic those of pituitary adenomas, and radical resection is often challenging in affected patients due to the hypervascularity of the tumor. Here, we describe the clinical and radiological features of this clinical entity.
METHODS: We identified 8 patients with LGG of the neurohypophysis. These patients underwent surgery from January 2007 to March 2017 at Toranomon Hospital. We retrospectively reviewed the clinical and radiological data for these patients.
RESULTS: The patients consisted of 5 men and 3 women with a mean age of 57 years. The presenting symptoms included visual disturbance in 7 patients and anterior pituitary dysfunction in 7 patients. No patients exhibited diabetes insipidus (DI). Preoperative magnetic resonance imaging (MRI) showed a thick anterior pituitary gland located anteriorly to the tumor in 3 patients and flow voids on T2-weighted images in 6 patients. All patients underwent transsphenoidal surgeries, and gross total resection was achieved in 4 patients. Postoperative morbidities included deterioration of anterior pituitary functions in 4 patients and permanent DI in 3 patients.
CONCLUSIONS: Anterior displacement of a thick anterior pituitary by a tumor combined with evidence of flow voids on preoperative MRI is helpful in the preoperative diagnosis of LGG of the neurohypophysis. Radical resection should be attempted in these tumors, especially during primary surgery, even though it is associated with postoperative pituitary dysfunction.
PMID: 29625306 [PubMed - as supplied by publisher]
https://ift.tt/2GFPic1
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου