Mechanisms and Biomarkers of Exercise-Induced Bronchoconstriction.

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Mechanisms and Biomarkers of Exercise-Induced Bronchoconstriction.

Immunol Allergy Clin North Am. 2018 May;38(2):165-182

Authors: Kippelen P, Anderson SD, Hallstrand TS

Abstract
Exercise is a common trigger of bronchoconstriction. In recent years, there has been increased understanding of the pathophysiology of exercise-induced bronchoconstriction. Although evaporative water loss and thermal changes have been recognized stimuli for exercise-induced bronchoconstriction, accumulating evidence points toward a pivotal role for the airway epithelium in orchestrating the inflammatory response linked to exercise-induced bronchoconstriction. Overproduction of inflammatory mediators, underproduction of protective lipid mediators, and infiltration of the airways with eosinophils and mast cells are all established contributors to exercise-induced bronchoconstriction. Sensory nerve activation and release of neuropeptides maybe important in exercise-induced bronchoconstriction, but further research is warranted.

PMID: 29631728 [PubMed - in process]

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